Controlling brain dynamics: Landscape and transition path for working memory.

ABSTRACT: Understanding the underlying dynamical mechanisms of the brain and controlling it is a crucial issue in brain science. The energy landscape and transition path approach provides a possible route to address these challenges. Here, taking working memory as an example, we quantified its landscape based on a large-scale macaque model. The working memory function is governed by the change of landscape and brain-wide state switching in response to the task demands. The kinetic transition path reveals that information flow follows the direction of hierarchical structure. Importantly, we propose a landscape control approach to manipulate brain state transition by modulating external stimulation or inter-areal connectivity, demonstrating the crucial roles of associative areas, especially prefrontal

SUBMITTER: Ye L 

PROVIDER: S-EPMC10503743 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature