Brain regions associated with olfactory dysfunction in first episode psychosis patients.

ABSTRACT:

Objectives

Olfactory dysfunction is reproducibly reported in psychotic disorders, particularly in association with negative symptoms. The superior frontal gyrus (SFG) has been frequently studied in patients with psychotic disorders, in particular with their associations with negative symptoms. The relationship between olfactory functions and brain structure has been studied in healthy controls (HCs). Nevertheless, the studies with patients with psychotic disorders are limited. Here we report the olfactory-brain relationship in a first episode psychosis (FEP) cohort through both hypothesis-driven (centred on the SFG) and data-driven approaches.

Methods

Using data from 88 HCs and 76 FEP patients, we evaluated the correlation between olfactory functions and structural/resting-s

SUBMITTER: Etyemez S 

PROVIDER: S-EPMC10503825 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature