Promoting antihepatocellular carcinoma activity against human HepG2 cells via pyridine substituted palladium complexes: in vitro evaluation and QSAR studies.

ABSTRACT: Bis(4-(4-nitrobenzyl)pyridine)dichloropalladium(II), [PdCl₂L¹₂], bis(2-amino-5-bromopyridine)dichloropalladium(II), [PdCl₂L²₂], bis(2,4-dimethylpyridine)dichloropalladium(II), [PdCl₂L³₂], bis(3,4-dimethylpyridine)dichloropalladium(II), [PdCl₂L⁴₂] were prepared. The spectroscopic techniques (FT-IR and ¹H-NMR, ¹³C-NMR) were used to characterize the compounds. Theoretical calculations were used to validate the experimental results. The LanL2DZ-based DFT/B3LYP method was used to define the most stable possible molecular structure for the complexes. Potential energy distribution analysis was performed to determine the theoretical vibration ban

SUBMITTER: Meral O 

PROVIDER: S-EPMC10503999 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature