Cerebellar deep brain stimulation for chronic post-stroke motor rehabilitation: a phase I trial.

ABSTRACT: Upper-extremity impairment after stroke remains a major therapeutic challenge and a target of neuromodulation treatment efforts. In this open-label, non-randomized phase I trial, we applied deep brain stimulation to the cerebellar dentate nucleus combined with renewed physical rehabilitation to promote functional reorganization of ipsilesional cortex in 12 individuals with persistent (1-3 years), moderate-to-severe upper-extremity impairment. No serious perioperative or stimulation-related adverse events were encountered, with participants demonstrating a seven-point median improvement on the Upper-Extremity Fugl-Meyer Assessment. All individuals who enrolled with partial preservation of distal motor function exceeded minimal clinically important difference regardless of time since stroke,

SUBMITTER: Baker KB 

PROVIDER: S-EPMC10504081 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature