A database of human predictive patch test data for skin sensitization.

ABSTRACT: Critical to the evaluation of non-animal tests are reference data with which to assess their relevance. Animal data are typically used because they are generally standardized and available. However, when regulatory agencies aim to protect human health, human reference data provide the benefit of not having to account for possible interspecies variability. To support the evaluation of non-animal approaches for skin sensitization assessment, we collected data from 2277 human predictive patch tests (HPPTs), i.e., human repeat insult patch tests and human maximization tests, for skin sensitization from 1555 publications. We recorded protocol elements and positive or negative outcomes, developed a scoring system to evaluate each test for reliability, and calculated traditional and non-tradition

SUBMITTER: Strickland J 

PROVIDER: S-EPMC10504114 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature