DNA methylome profiling of blood to identify individuals in a pair of monozygotic twins.

ABSTRACT:

Background

Short tandem repeat (STR) markers cannot be used to distinguish between genetically identical monozygotic (MZ) twins, causing problems in a case with an MZ twin as a suspect. Many studies have shown that in older MZ twins, there are significant differences in overall content and genomic distribution of methylation.

Objective

In this study, we analyzed the DNA methylome profile of blood to identify recurrent differentially methylated CpG sites (DMCs) to discriminate between MZ twins.

Methods

Blood samples were collected from 47 paired MZ twins. We performed the DNA methylation profiling using the HumanMethylation EPIC BeadChip platform and identified recurrent DMCs between MZ twins. Then, Kyoto Encyclopedia of Genes and Genomes (KEGG), Gene Ontology (GO), an

SUBMITTER: Kim JY 

PROVIDER: S-EPMC10504115 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature