Breast cancer and incidence of type 2 diabetes mellitus: a systematic review and meta-analysis.

ABSTRACT:

Purpose

Breast cancer and its treatments may increase the risk of type 2 diabetes (T2D). We conducted a systematic review and meta-analysis to investigate the association between breast cancer and the incidence of T2D overall, and according to breast cancer treatments.

Methods

We searched PubMed, Embase and references of relevant papers for studies on breast cancer, breast cancer treatment, and subsequent T2D risk. Using random-effects models, we calculated effect estimates and associated 95% confidence intervals of the association between breast cancer, adjuvant breast cancer treatments (i.e., endocrine therapy (tamoxifen, aromatase inhibitors, and combined) and chemotherapy), and subsequent T2D. We used funnel plots to assess publication bias.

Results

Among 15 eligi

SUBMITTER: Jordt N 

PROVIDER: S-EPMC10504120 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature