Comparative effectiveness and safety of 36 therapies or interventions for pregnancy outcomes with recurrent implantation failure: a systematic review and network meta-analysis.

ABSTRACT:

Purpose

To investigate the effectiveness and safety of 36 different therapies for recurrent implantation failure (RIF) patients.

Methods

We searched PubMed, Embase, the Cochrane Library (CENTRAL), Web of Science, and China National Knowledge Internet (CNKI) from inception to August 24, 2022, with language in both English and Chinese. Randomized controlled trials (RCTs) and observational studies that provided data with one of pregnancy outcomes on RIF patients were included in the network meta-analysis (NMA). The odds ratios (OR) and 95% credible interval (CrI) on pregnancy outcomes were summarized by NMA with a random-effects model. We also analyzed data from only RCTs and compared whether the optimal treatment is the same for different failed embryo transfer attempts.

Re

SUBMITTER: He Y 

PROVIDER: S-EPMC10504168 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature