Higher serum uric acid is associated with poorer cognitive performance in healthy middle-aged people: a cross-sectional study.

ABSTRACT: Age-related cognitive impairment can occur many years before the onset of the clinical symptoms of dementia. Uric acid (UA), a metabolite of purine-rich foods, has been shown to be positively associated with improved cognitive function, but such association remains controversial. Moreover, most of the previous studies investigating the association included elderly participants with memory-related diseases. Therefore, the present study aimed at investigating whether serum UA (sUA) is associated with cognitive performance in healthy middle-aged individuals. We conducted a cross-sectional study on a cohort of middle-aged individuals (40-60 years old) who participated in the Qatar Biobank. The participants had no memory-related diseases, schizophrenia, stroke, or brain damage. They were divide

SUBMITTER: Khaled Y 

PROVIDER: S-EPMC10504193 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature