Selective effects of estradiol on human corneal endothelial cells.

ABSTRACT: In Fuchs endothelial corneal dystrophy (FECD), mitochondrial and oxidative stresses in corneal endothelial cells (HCEnCs) contribute to cell demise and disease progression. FECD is more common in women than men, but the basis for this observation is poorly understood. To understand the sex disparity in FECD prevalence, we studied the effects of the sex hormone 17-β estradiol (E2) on growth, oxidative stress, and metabolism in primary cultures of HCEnCs grown under physiologic ([O₂]_2.5) and hyperoxic ([O₂]_A) conditions. We hypothesized that E2 would counter the damage of oxidative stress generated at [O₂]_A. HCEnCs were treated with or without E2 (10 nM) for 7-10 days under both conditions. Treatment with E2 did not significan

SUBMITTER: Han S 

PROVIDER: S-EPMC10504266 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature