Dataset Information

SARS-CoV-2 seroconversion in children attending daycare versus adults in Germany between October 2020 and June 2021.

ABSTRACT:

Background

Data on seroconversion rates after SARS-CoV-2 infection in young children (<6 years) is scarce. The present study compares seroconversion rates between young children and adults and identifies associated factors.

Methods

The COALA study ("Corona-outbreak-related examinations in daycare centers") investigated transmission dynamics of SARS-CoV-2 in daycare centers and associated households (10/2020-06/2021). 114 individuals tested positive for SARS-CoV-2 through PCR either prior to the study period by health authorities or in PCR testing during the study period. Two capillary blood samples were obtained within five weeks consecutively and tested for SARS-CoV-2 IgG-antibodies (second sampling depending on positive PCR). Results from 91 participants (38 young children 1-6 years, 53 adults) were included in the analyses.

Results

Seroconversion rate in young children is significantly higher than in adults (97.4% versus 66%). High viral load and longer time interval between the probable date of infection and antibody testing are associated with seroconversion.

Conclusions

Our findings depict substantial development of specific antibodies in young children after SARS-CoV-2 infection. This may provide temporary protection from re-infection for young children or severe disease for this age group.

SUBMITTER: Kubisch U

PROVIDER: S-EPMC10504330 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

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Publications

SARS-CoV-2 seroconversion in children attending daycare versus adults in Germany between October 2020 and June 2021.

Kubisch Ulrike U Sandoni Anna A Wurm Juliane J Schienkiewitz Anja A Schlaud Martin M Kuttig Tim T Finkel Bianca B Jordan Susanne S Loss Julika J

Communications medicine 20230915 1

<h4>Background</h4>Data on seroconversion rates after SARS-CoV-2 infection in young children (<6 years) is scarce. The present study compares seroconversion rates between young children and adults and identifies associated factors.<h4>Methods</h4>The COALA study ("Corona-outbreak-related examinations in daycare centers") investigated transmission dynamics of SARS-CoV-2 in daycare centers and associated households (10/2020-06/2021). 114 individuals tested positive for SARS-CoV-2 through PCR eithe ...[more]

PMID: 37714948

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Dataset Information

SARS-CoV-2 seroconversion in children attending daycare versus adults in Germany between October 2020 and June 2021.

Background

Methods

Results

Conclusions

Publications

SARS-CoV-2 seroconversion in children attending daycare versus adults in Germany between October 2020 and June 2021.

Similar Datasets

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