Mediation of the association between disadvantaged neighborhoods and cortical microstructure by body mass index.

ABSTRACT:

Background

Living in a disadvantaged neighborhood is associated with worse health outcomes, including brain health, yet the underlying biological mechanisms are incompletely understood. We investigated the relationship between neighborhood disadvantage and cortical microstructure, assessed as the T1-weighted/T2-weighted ratio (T1w/T2w) on magnetic resonance imaging, and the potential mediating roles of body mass index (BMI) and stress, as well as the relationship between trans-fatty acid intake and cortical microstructure.

Methods

Participants comprised 92 adults (27 men; 65 women) who underwent neuroimaging and provided residential address information. Neighborhood disadvantage was assessed as the 2020 California State area deprivation index (ADI). The T1w/T2w ratio was cal

SUBMITTER: Kilpatrick LA 

PROVIDER: S-EPMC10504354 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature