DrForna: visualization of cotranscriptional folding.

ABSTRACT:

Motivation

Understanding RNA folding at the level of secondary structures can give important insights concerning the function of a molecule. We are interested to learn how secondary structures change dynamically during transcription, as well as whether particular secondary structures form already during or only after transcription. While different approaches exist to simulate cotranscriptional folding, the current strategies for visualization are lagging behind. New, more suitable approaches are necessary to help with exploring the generated data from cotranscriptional folding simulations.

Results

We present DrForna, an interactive visualization app for viewing the time course of a cotranscriptional RNA folding simulation. Specifically, users can scroll along the time axis a

SUBMITTER: Tanasie AR 

PROVIDER: S-EPMC10504468 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature