Molecular docking analysis of imidazole quinolines with gingipain R from Porphyromonas gingivalis.
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ABSTRACT:
SUBMITTER: Reddy KR
PROVIDER: S-EPMC10504515 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
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Molecular docking analysis of imidazole quinolines with gingipain R from <i>Porphyromonas gingivalis</i>.
Reddy Kanumuru Rahul KR Rengasamy Gayathri G Sekaran Surya S Veeraraghavan Vishnu Priya VP Sankaran Kavitha K Eswaramoorthy Rajalakshmanan R
Bioinformation 20230101 1
<i>Porphyromonas gingivalis</i> is known to produce major virulence factor, Gingipain R that could penetrate the gingivae and cause tissue destruction. In this research we aim to target the gingipain R protein with imidazole quinoline derivatives (1-6) via insilico means. Molecular docking results show, compounds (1-6) have better affinity and amino acid interactions compared to the standard clinically proven drugs used as control group, and they obey Lipinski's rule of five and can be used as p ...[more]
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