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Molecular docking analysis of the tumor protein beta arrestin-1 with oxadiazole compounds.

ABSTRACT: Beta arrestins are a family of adaptor proteins that help in the regulation of signaling and trafficking of various G protein coupled receptors (GPCRs). Six oxadiazole derivatives taken from literature are analyzed for anti-cancer properties. The toxicity profiles of all the drugs were similar to Tamoxifen used as control. Data shows that compounds 2, 4, and 6 exhibited comparably significant molecular interactions with the cancerous protein for further consideration.

SUBMITTER: Sharma V

PROVIDER: S-EPMC10504516 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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Molecular docking analysis of the tumor protein beta arrestin-1 with oxadiazole compounds.

Sharma Vipra V Rengasamy Gayathri G Sekaran Surya S Sankaran Kavitha K Veeraraghavan Vishnu Priya VP Eswaramoorthy Rajalakshmanan R

Bioinformation 20230131 1

Beta arrestins are a family of adaptor proteins that help in the regulation of signaling and trafficking of various G protein coupled receptors (GPCRs). Six oxadiazole derivatives taken from literature are analyzed for anti-cancer properties. The toxicity profiles of all the drugs were similar to Tamoxifen used as control. Data shows that compounds 2, 4, and 6 exhibited comparably significant molecular interactions with the cancerous protein for further consideration. ...[more]

PMID: 37720289

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