Preimplantation genetic testing for sickle cell disease: a cost-effectiveness analysis.

ABSTRACT:

Objective

To evaluate the cost-effectiveness of in vitro fertilization with preimplantation genetic testing for monogenic disease (IVF + PGT-M) in the conception of a nonsickle cell disease (non-SCD) individual compared with standard of care treatment for a naturally conceived, sickle cell disease (SCD)-affected individual.

Design

A Markov simulation model was constructed to evaluate a one-time IVF + PGT-M treatment compared with the lifetime standard of care costs of treatment for an individual potentially born with SCD. Using an annual discount rate of 3% for cost and outcome measures, quality-adjusted life years were constructed from utility weights and life expectancy values and then used as the effectiveness measurement. An incremental cost-effectiveness ratio was calcu

SUBMITTER: Combs JC 

PROVIDER: S-EPMC10504548 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature