High-coverage genome of the Tyrolean Iceman reveals unusually high Anatolian farmer ancestry.

ABSTRACT: The Tyrolean Iceman is known as one of the oldest human glacier mummies, directly dated to 3350-3120 calibrated BCE. A previously published low-coverage genome provided novel insights into European prehistory, despite high present-day DNA contamination. Here, we generate a high-coverage genome with low contamination (15.3×) to gain further insights into the genetic history and phenotype of this individual. Contrary to previous studies, we found no detectable Steppe-related ancestry in the Iceman. Instead, he retained the highest Anatolian-farmer-related ancestry among contemporaneous European populations, indicating a rather isolated Alpine population with limited gene flow from hunter-gatherer-ancestry-related populations. Phenotypic analysis revealed that the Iceman likely had darker ski

SUBMITTER: Wang K 

PROVIDER: S-EPMC10504632 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature