Better together: Non-additive interactions between schizophrenia risk genes.
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ABSTRACT:
SUBMITTER: Deans PJM
PROVIDER: S-EPMC10504666 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
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Better together: Non-additive interactions between schizophrenia risk genes.
Deans P J Michael PJM Brennand Kristen J KJ
Cell genomics 20230913 9
Zhang, Zhang, Forrest <i>et al</i> combine allele-specific open chromatin (ASoC) mapping and CRISPR-editing to evaluate the functional impact of schizophrenia risk variants on human neuronal gene expression, synaptic development, and function. In doing so, they uncover surprising non-additive effects between target genes regulated by the same risk variant. ...[more]
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