Better together: Non-additive interactions between schizophrenia risk genes.

ABSTRACT: Zhang, Zhang, Forrest et al combine allele-specific open chromatin (ASoC) mapping and CRISPR-editing to evaluate the functional impact of schizophrenia risk variants on human neuronal gene expression, synaptic development, and function. In doing so, they uncover surprising non-additive effects between target genes regulated by the same risk variant.

SUBMITTER: Deans PJM 

PROVIDER: S-EPMC10504666 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature