Scaling, selection, and evolutionary dynamics of the mitotic spindle.

ABSTRACT:

Background

Cellular structures such as the nucleus, Golgi, centrioles, and spindle show remarkable diversity between species, but the mechanisms that produce these variations in cell biology are not known.

Results

Here we investigate the mechanisms that contribute to variations in morphology and dynamics of the mitotic spindle, which orchestrates chromosome segregation in all Eukaryotes and positions the division plane in many organisms. We use high-throughput imaging of the first division in nematodes to demonstrate that the measured effects of spontaneous mutations, combined with stabilizing selection on cell size, are sufficient to quantitatively explain both the levels of within-species variation in the spindle and its diversity over ∼100 million years of evolution. Furt

SUBMITTER: Farhadifar R 

PROVIDER: S-EPMC10504684 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature