Chalcone/1,3,4-Oxadiazole/Benzimidazole hybrids as novel anti-proliferative agents inducing apoptosis and inhibiting EGFR & BRAFV^600E.

ABSTRACT:

Introduction

One of the most robust global challenges and difficulties in the 21st century is cancer. Treating cancer is a goal which continues to motivate researchers to innovate in design and development of new treatments to help battle the disease.

Objectives

Our objective was developing new antiapoptotic hybrids based on biologically active heterocyclic motifs "benzimidazole?oxadiazole-chalcone hybrids'' that had shown promising ability to inhibit EGFR and induce apoptosis. We expected these scaffolds to display anticancer activity via inhibition of BRAF, EGFR, and Bcl-2 and induction of apoptosis through activation of caspases.

Methods

The new hybrids 7a-x were evaluated for their anti-proliferative, EGFR & BRAF^V600E inhibitory, and apoptosis induction

SUBMITTER: Hagar FF 

PROVIDER: S-EPMC10504751 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature