Systematic characterization of a non-transgenic Aβ_1-42 amyloidosis model: synaptic plasticity and memory deficits in female and male mice.

ABSTRACT:

Background

The amyloid-β (Aβ) cascade is one of the most studied theories linked to AD. In multiple models, Aβ accumulation and dyshomeostasis have shown a key role in AD onset, leading to excitatory/inhibitory imbalance, the impairments of synaptic plasticity and oscillatory activity, and memory deficits. Despite the higher prevalence of Alzheimer's disease (AD) in women compared to men, the possible sex difference is scarcely explored and the information from amyloidosis transgenic mice models is contradictory. Thus, given the lack of data regarding the early stages of amyloidosis in female mice, the aim of this study was to systematically characterize the effect of an intracerebroventricular (icv.) injection of Aβ_1-42 on hippocampal-dependent memory, and on associated

SUBMITTER: Jimenez-Herrera R 

PROVIDER: S-EPMC10504764 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature