Brazilian Expert Consensus for NTRK Gene Fusion Testing in Solid Tumors.

ABSTRACT: Oncogenic neurotrophic tropomyosin receptor kinase gene fusions occur in less than 1% of common cancers. These mutations have emerged as new biomarkers in cancer genomic profiling with the approval of selective drugs against tropomyosin receptor kinase fusion proteins. Nevertheless, the optimal pathways and diagnostic platforms for this biomarker's screening and genomic profiling have not been defined and remain a subject of debate. A panel of national experts in molecular cancer diagnosis and treatment was convened by videoconference and suggested topics to be addressed in the literature review. The authors proposed a testing algorithm for oncogenic neurotrophic tropomyosin receptor kinase gene fusion screening and diagnosis for the Brazilian health system. This review aims to discuss the

SUBMITTER: Petaccia de Macedo M 

PROVIDER: S-EPMC10504829 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature