The Regenerative Power of Stem Cells: Treating Bleomycin-Induced Lung Fibrosis.

ABSTRACT: Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease with no known cure, characterized by the formation of scar tissue in the lungs, leading to respiratory failure. Although the exact cause of IPF remains unclear, the condition is thought to result from a combination of genetic and environmental factors. One of the most widely used animal models to study IPF is the bleomycin-induced lung injury model in mice. In this model, the administration of the chemotherapeutic agent bleomycin causes pulmonary inflammation and fibrosis, which closely mimics the pathological features of human IPF. Numerous recent investigations have explored the functions of various categories of stem cells in the healing process of lung injury induced by bleomycin in mice, documenting the bene

SUBMITTER: Vats A 

PROVIDER: S-EPMC10505024 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature