CAR-T Cell Therapy: the Efficacy and Toxicity Balance.

ABSTRACT:

Purpose of review

Chimeric antigen receptor (CAR) T cell therapy is an immunotherapy that has resulted in tremendous progress in the treatment of patients with B cell malignancies. However, the remarkable efficacy of therapy is not without significant safety concerns. Herein, we will review the unique and potentially life-threatening toxicities associated with CAR-T cell therapy and their association with treatment efficacy.

Recent findings

Currently, CAR-T cell therapy is approved for the treatment of B cell relapsed or refractory leukemia and lymphoma, and most recently, multiple myeloma (MM). In these different diseases, it has led to excellent complete and overall response rates depending on the patient population and therapy. Despite promising efficacy, CAR-T cell thera

SUBMITTER: Chohan KL 

PROVIDER: S-EPMC10505056 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature