Bioinformatical analysis of the key differentially expressed genes for screening potential biomarkers in Wilms tumor.

ABSTRACT: Wilms tumor (WT) is the most common pediatric renal malignant tumor in the world. Overall, the prognosis of Wilms tumor is very good. However, the prognosis of patients with anaplastic tumor histology or disease relapse is still poor, and their recurrence rate, metastasis rate and mortality are significantly increased compared with others. Currently, the combination of histopathological examination and molecular biology is essential to predict prognosis and guide the treatment. However, the molecular mechanism has not been well studied. Genetic profiling may be helpful in some way. Hence, we sought to identify novel promising biomarkers of WT by integrating bioinformatics analysis and to identify genes associated with the pathogenesis of WT. In the presented study, the NCBI Gene Expression

SUBMITTER: Cai L 

PROVIDER: S-EPMC10505208 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature