Targeted co-delivery of curcumin and erlotinib by MoS₂ nanosheets for the combination of synergetic chemotherapy and photothermal therapy of lung cancer.

ABSTRACT:

Background

Curcumin (Cur), a bioactive component of Chinese traditional medicine, has demonstrated inhibitory properties against cancer cell proliferation while synergistically enhancing the anticancer efficacy of erlotinib (Er). However, the individual limitations of both drugs, including poor aqueous solubility, lack of targeting ability, short half-life, etc., and their distinct pharmacokinetic profiles mitigate or eliminate their combined antitumor potential.

Results

In this study, we developed a molybdenum disulfide (MoS₂)-based delivery system, functionalized with polyethylene glycol (PEG) and biotin, and co-loaded with Cur and Er, to achieve efficient cancer therapy. The MoS₂-PEG-Biotin-Cur/Er system effectively converted near-infrared (NIR) ligh

SUBMITTER: Chen Z 

PROVIDER: S-EPMC10505307 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature