The association between prenatal famine, DNA methylation and mental disorders: a systematic review and meta-analysis.

ABSTRACT:

Background

Undernutrition in pregnant women is an unfavorable environmental condition that can affect the intrauterine development via epigenetic mechanisms and thus have long-lasting detrimental consequences for the mental health of the offspring later in life. One epigenetic mechanism that has been associated with mental disorders and undernutrition is alterations in DNA methylation. The effect of prenatal undernutrition on the mental health of adult offspring can be analyzed through quasi-experimental studies such as famine studies. The present systematic review and meta-analysis aims to analyze the association between prenatal famine exposure, DNA methylation, and mental disorders in adult offspring. We further investigate whether altered DNA methylation as a result of prenatal

SUBMITTER: Eichenauer H 

PROVIDER: S-EPMC10505322 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature