Reproducibility of Glycemic Measures Among Dysglycemic Youth and Adults in the RISE Study.

ABSTRACT:

Aims

Previous work found poor reproducibility for measures of glycemia in individuals at risk for dysglycemia. Differences between youth and adults have not been assessed. Using youth and adults in the Restoring Insulin Secretion Study, we tested variability and classification concordance for hemoglobin A1C (HbA1c), fasting and 2-hour glucose from oral glucose tolerance tests (OGTTs).

Methods

HbA1c and glucose on repeated samples obtained ∼6 weeks apart were compared in 66 youth (mean age 14.2 years) and 354 adults (52.7 years). Changes, coefficient of variation (CV), and concordance of diagnostic categories between the 2 visits were compared.

Results

Mean difference between the 2 visits in HbA1c was higher in youth than adults (P < .001), while fasting glucose was si

SUBMITTER: Tjaden AH 

PROVIDER: S-EPMC10505524 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature