Longitudinal MRI Shows Progressive Decline in Pancreas Size and Altered Pancreas Shape in Type 1 Diabetes.

ABSTRACT:

Context

Individuals with type 1 diabetes (T1D) have a smaller pancreas, but longitudinal changes in pancreas size and shape are unclear.

Objective

We monitored changes in pancreas size and shape after diagnosis with T1D.

Design

We conducted a prospective cohort study at an academic medical center between 2014 and 2022.

Patients and healthy controls

Individuals with T1D (n = 91) or controls (n = 90) underwent magnetic resonance imaging (MRI) of the pancreas, including longitudinal MRI in 53 individuals with new-onset T1D.

Intervention

Interventions included MRI and continuous glucose monitoring (CGM).

Main outcome measures

Pancreas size and shape were measured from MRI. For participants who used CGM, measures of glycemic variability were calculated

SUBMITTER: Wright JJ 

PROVIDER: S-EPMC10505530 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature