Increased GH/IGF-I Axis Activity Relates to Lower Hepatic Lipids and Phosphor Metabolism.

ABSTRACT:

Context

Non-alcoholic fatty liver disease (NAFLD) is a leading causes of liver-related morbidity and mortality. While data on acromegaly, a state of chronic growth hormone (GH)/insulin-like growth factor I (IGF-I) excess, suggest an inverse relationship with intrahepatic lipid (IHL) content, less is known about the impact of the GH/IGF-I axis on IHL, lipid composition, and phosphor metabolites in individuals without disorders of GH secretion.

Objective

The aim was to investigate the relation between activity of the GH/IGF-I axis and IHL content and phosphor metabolism.

Methods

We performed a cross-sectional study in 59 otherwise metabolically healthy individuals (30 females), of which 16 met the criteria of NAFLD with IHL of ≥5.6%. The GH/IGF-I axis was evaluated in a

SUBMITTER: Fellinger P 

PROVIDER: S-EPMC10505545 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature