Opening a window to skin biomarkers for diabetes stage with optoacoustic mesoscopy.

ABSTRACT: Being the largest and most accessible organ of the human body, the skin could offer a window to diabetes-related complications on the microvasculature. However, skin microvasculature is typically assessed by histological analysis, which is not suited for applications to large populations or longitudinal studies. We introduce ultra-wideband raster-scan optoacoustic mesoscopy (RSOM) for precise, non-invasive assessment of diabetes-related changes in the dermal microvasculature and skin micro-anatomy, resolved with unprecedented sensitivity and detail without the need for contrast agents. Providing unique imaging contrast, we explored a possible role for RSOM as an investigational tool in diabetes healthcare and offer the first comprehensive study investigating the relationship between differ

SUBMITTER: He H 

PROVIDER: S-EPMC10505608 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature