Targeted delivery of autoantigen to dendritic cells prevents development of spontaneous uveitis.

ABSTRACT: Restoration of immunological tolerance to self antigens has been a major drive in understanding the mechanisms of, and developing new treatments for, autoimmune and autoinflammatory disease. Sessile dendritic cells (DC) are considered the main instruments underpinning immunological tolerance particularly the CD205⁺ (DEC205⁺) cDC1 subset in contrast to DCIR2⁺ cDC2 which mediate immunogenicity. Targeting DC using autoantigen peptide-antibody fusion proteins has been a well explored methodology for inducing tolerance. Here we show that subcutaneous (s.c.) inoculation of hen-egg lysozyme (HEL)-DEC205 Ig fusion prevents the development of spontaneous uveoretinitis (experimental autoimmune uveoretinitis, EAU) in a transgenic mouse model generated by crossing inte

SUBMITTER: Klaska IP 

PROVIDER: S-EPMC10505613 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature