The nutrition and immunity (nutrIMM) study: protocol for a non-randomized, four-arm parallel-group, controlled feeding trial investigating immune function in obesity and type 2 diabetes.

ABSTRACT:

Introduction

Individuals with obesity and/or type 2 diabetes are at higher risk of infection and have worse prognoses compared to healthy individuals. Several factors may influence immune responses in this population, including high adiposity, hyperglycemia, and unhealthy dietary habits. However, there is insufficient data on the independent or clustered contribution of these factors to obesity-related immune dysfunction, especially accounting for dietary intake. This study aims to establish the independent contribution of obesity and hyperglycemia to immune dysfunction independent of diet in adults with and without obesity with or without type 2 diabetes.

Methods

The Nutrition and Immunity (nutrIMM) study is a single-centre, non-randomized, four-arm, parallel-group, control

SUBMITTER: Braga Tibaes JR 

PROVIDER: S-EPMC10505731 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature