Persistence of immunological memory as a potential correlate of long-term, vaccine-induced protection against Ebola virus disease in humans.

ABSTRACT:

Introduction

In the absence of clinical efficacy data, vaccine protective effect can be extrapolated from animals to humans, using an immunological biomarker in humans that correlates with protection in animals, in a statistical approach called immunobridging. Such an immunobridging approach was previously used to infer the likely protective effect of the heterologous two-dose Ad26.ZEBOV, MVA-BN-Filo Ebola vaccine regimen. However, this immunobridging model does not provide information on how the persistence of the vaccine-induced immune response relates to durability of protection in humans.

Methods and results

In both humans and non-human primates, vaccine-induced circulating antibody levels appear to be very stable after an initial phase of contraction and are maintained

SUBMITTER: McLean C 

PROVIDER: S-EPMC10505757 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature