Adrenal steroid metabolites and bone status in patients with adrenal incidentalomas and hypercortisolism.

ABSTRACT:

Background

Autonomous cortisol secretion (ACS), resulting from cortisol-producing adenomas (CPA), causes endogenous steroid-induced osteoporosis (SIOP). However, the risk of endogenous SIOP cannot be explained by cortisol excess alone, and how other steroid metabolites affect bone status is unclear.

Methods

ACS was diagnosed as serum cortisol ≥1.8 μg/dL after the 1-mg dexamethasone suppression test (DST-cortisol). Using liquid chromatography tandem mass spectrometry, 21 plasma steroid metabolites were measured in 73 patients with ACS and 85 patients with non-functioning adrenal tumors (NFAT). Expression of steroidogenic enzymes and relevant steroid metabolites were analyzed in some of CPA tissues.

Findings

Discriminant and principal component analyses distinguished st

SUBMITTER: Nakao H 

PROVIDER: S-EPMC10505782 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature