Contrast-enhanced ultrasound imaging for monitoring the efficacy of near-infrared photoimmunotherapy.

ABSTRACT:

Background

Near-infrared photoimmunotherapy (NIR-PIT) is a promising cancer therapy combining NIR-light irradiation with an antibody and IR700DX, a light-sensitive substance, to destroy tumours. However, homogeneous irradiation is difficult because the light varies depending on the distance and tissue environment. Therefore, markers that indicate sufficient irradiation are necessary. Nanoparticles sized 10∼200 nm show enhanced permeation and retention within tumours, which is further enhanced via NIR-PIT (super enhanced permeability and retention, SUPR). We aimed to monitor the effectiveness of NIR-PIT by measuring SUPR.

Methods

A xenograft mouse tumour model was established by inoculating human cancer cells in both buttocks of Balb/C-nu/nu mice, and NIR-PIT was performed on

SUBMITTER: Matsuoka K 

PROVIDER: S-EPMC10505829 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature