Genomic Index of Sensitivity to Chemotherapy for Triple Negative Breast Cancer.

ABSTRACT:

Objective

Patients with triple-negative breast cancer (TNBC) frequently develop resistance to chemotherapy. Studies have shown that microRNAs (miRNAs) are often aberrantly expressed in TNBC and are associated with drug resistance. However, a prognostic strategy that correlates miRNAs with chemotherapy resistance remains largely unknown.

Methods

To identify breast cancer chemoresistance-associated miRNAs, the miRNA microarray dataset GSE71142 was downloaded from the Gene Expression Omnibus database. Differentially expressed miRNAs (DE-miRNAs) in chemoresistant groups were identified using the LIMMA package in R. Potential target genes were predicted using the miRTarBase 9. Functional and pathway enrichment analyses was done using WebGestalt. A protein-protein interaction netw

SUBMITTER: Sameer C A 

PROVIDER: S-EPMC10505887 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature