Premature morbidity and mortality associated with potentially undiagnosed familial hypercholesterolemia in the general population.

ABSTRACT:

Background

Familial hypercholesterolemia (FH) is common, but underdiagnosed, and few systematic early screening programs exist.

Objective

To assess health outcomes among those with a recorded diagnosis of FH and potential cases of FH with no recorded diagnosis.

Methods

Retrospective cohort study using the UK Clinical Practice Research Datalink. Records of adults were classified as diagnosed FH (FH_Coded), or via accepted algorithms using LDL-C and clinical characteristics as potential FH (FH_Potential) or unlikely FH (FH_Unlikely) using the DLCN or EUROASPIRE criteria (but no record of FH). Outcomes assessed were premature cardiovascular (CV) events, premature deaths and life expectancy.

Results

Among 1,729,046 individuals free fro

SUBMITTER: Ray KK 

PROVIDER: S-EPMC10506055 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature