Early discontinuation of combination antibiotic therapy in severe community-acquired pneumonia: a retrospective cohort study.

ABSTRACT:

Background

Severe community-acquired pneumonia (SCAP) is commonly treated with an empiric combination therapy, including a macrolide, or a quinolone and a β-lactam. However, the risk of Legionella pneumonia may lead to a prolonged combination therapy even after negative urinary antigen tests (UAT).

Methods

We conducted a retrospective cohort study in a French intensive care unit (ICU) over 6 years and included all the patients admitted with documented SCAP. All patients received an empirical combination therapy with a β-lactam plus a macrolide or quinolone, and a Legionella UAT was performed. Macrolide or quinolone were discontinued when the UAT was confirmed negative. We examined the clinical and epidemiological features of SCAP and analysed the independent factors associat

SUBMITTER: Guillot P 

PROVIDER: S-EPMC10506273 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature