Associations between telomere attrition, genetic variants in telomere maintenance genes, and non-small cell lung cancer risk in the Jammu and Kashmir population of North India.

ABSTRACT:

Background

Telomeres are repetitive DNA sequences located at the ends of chromosomes, playing a vital role in maintaining chromosomal integrity and stability. Dysregulation of telomeres has been implicated in the development of various cancers, including non-small cell lung cancer (NSCLC), which is the most common type of lung cancer. Genetic variations within telomere maintenance genes may influence the risk of developing NSCLC. The present study aimed to evaluate the genetic associations of select variants within telomere maintenance genes in a population from Jammu and Kashmir, North India, and to investigate the relationship between telomere length and NSCLC risk.

Methods

We employed the cost-effective and high-throughput MassARRAY MALDI-TOF platform to assess the geneti

SUBMITTER: Bhat GR 

PROVIDER: S-EPMC10506276 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature