Treatment of Metastatic Colorectal Cancer: ASCO Guideline.

ABSTRACT:

Purpose

To develop recommendations for treatment of patients with metastatic colorectal cancer (mCRC).

Methods

ASCO convened an Expert Panel to conduct a systematic review of relevant studies and develop recommendations for clinical practice.

Results

Five systematic reviews and 10 randomized controlled trials met the systematic review inclusion criteria.

Recommendations

Doublet chemotherapy should be offered, or triplet therapy may be offered to patients with previously untreated, initially unresectable mCRC, on the basis of included studies of chemotherapy in combination with anti-vascular endothelial growth factor antibodies. In the first-line setting, pembrolizumab is recommended for patients with mCRC and microsatellite instability-high or deficient mismatc

SUBMITTER: Morris VK 

PROVIDER: S-EPMC10506310 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature