Regulation of sexually dimorphic placental adaptation in LPS exposure-induced intrauterine growth restriction.

ABSTRACT:

Background

Sexual dimorphism in placental physiology affects the functionality of placental adaptation during adverse pregnancy. Defects of placental function compromise fetal programming, affecting the offspring's adult life. However, studies focusing on the relationship between sex-specific placental adaptation and consequent fetal maldevelopment under sub-optimal uterus milieu are still elusive.

Methods

Here, we investigated the effects of maternal lipopolysaccharide (LPS) exposure between placental sex. Pregnant ICR mice received intraperitoneal injection of phosphate-buffered saline or 100, 200, and 400 µg/kg LPS on the gestational day (GD) 15.5. To determine whether prenatal maternal LPS exposure resulted in complicated pregnancy outcomes, survival rate of embryos was

SUBMITTER: Jeong DS 

PROVIDER: S-EPMC10506314 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature