LFA-1 knockout inhibited the tumor growth and is correlated with treg cells.

ABSTRACT: Cancer immunotherapy has been proven to be clinically effective in multiple types of cancers. Lymphocyte function-associated antigen 1 (LFA-1), a member of the integrin family of adhesion molecules, is expressed mainly on αβ T cells. LFA-1 is associated with tumor immune responses, but its exact mechanism remains unknown. Here, two kinds of mice tumor model of LFA-1 knockout (LFA-1^-/-) mice bearing subcutaneous tumor and Apc ^Min/+;LFA-1^-/- mice were used to confirm that LFA-1 knockout resulted in inhibition of tumor growth. Furthermore, it also demonstrated that the numbers of regulatory T cells (Treg cells) in the spleen, blood, mesenteric lymph nodes were decreased in LFA-1^-/- mice, and the numbers of Treg cells in mesenteric lymph nodes were a

SUBMITTER: Niu T 

PROVIDER: S-EPMC10506322 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature