TLR2 is non-redundant in the population and subpopulation responses to <i>Mycobacterium tuberculosis</i> in macrophages and <i>in vivo</i>.

ABSTRACT: Tuberculosis (TB), caused by the pathogenic bacterium Mycobacterium tuberculosis (Mtb), is a global health threat. Targeting host pathways that modulate protective or harmful components of inflammation has been proposed as a therapeutic strategy that could aid sterilization or mitigate TB-associated permanent tissue damage. In purified form, many Mtb components can activate innate immune pathways. However, knowledge of the pathways that contribute most to the observed response to live Mtb is incomplete, limiting the possibility of precise intervention. We took a systematic, unbiased approach to define the pathways that drive the earliest immune response to Mtb. Using a macrophage model of infection, we compared the bulk transcriptional response to infection with the response to a pa

SUBMITTER: Jani C 

PROVIDER: S-EPMC10506474 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature