Paramagnetic Mn₈Fe₄-co-Polystyrene Nanobeads as a Potential T₁-T₂ Multimodal Magnetic Resonance Imaging Contrast Agent with In Vivo Studies.

ABSTRACT: In developing a cluster-nanocarrier design, as a magnetic resonance imaging contrast agent, we have investigated the enhanced relaxivity of a manganese and iron-oxo cluster grafted within a porous polystyrene nanobead with increased relaxivity due to a higher surface area. The synthesis of the cluster-nanocarrier for the cluster Mn₈Fe₄O₁₂(O₂CC₆H₄CH═CH₂)₁₆(H₂O)₄, cross-linked with polystyrene (the nanocarrier), under miniemulsion conditions is described. By including a branched hydrophobe, iso-octane, the resulting nanobeads are porous and ∼70 nm in diameter. The increased surface area of the nanobeads compared to nonporous nanobeads leads to an enhancement in relaxivity;

SUBMITTER: Dahanayake V 

PROVIDER: S-EPMC10506655 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature