Epigenetic signature of human immune aging in the GESTALT study.

ABSTRACT: Age-associated DNA methylation in blood cells convey information on health status. However, the mechanisms that drive these changes in circulating cells and their relationships to gene regulation are unknown. We identified age-associated DNA methylation sites in six purified blood-borne immune cell types (naive B, naive CD4⁺ and CD8⁺ T cells, granulocytes, monocytes, and NK cells) collected from healthy individuals interspersed over a wide age range. Of the thousands of age-associated sites, only 350 sites were differentially methylated in the same direction in all cell types and validated in an independent longitudinal cohort. Genes close to age-associated hypomethylated sites were enriched for collagen biosynthesis and complement cascade pathways, while genes close

SUBMITTER: Roy R 

PROVIDER: S-EPMC10506794 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature