Single-dose effects of methylphenidate and atomoxetine on functional connectivity during an n-back task in boys with ADHD.

ABSTRACT:

Rationale

Working memory deficits and associated neurofunctional abnormalities are frequently reported in attention-deficit/hyperactivity disorder (ADHD). Methylphenidate and atomoxetine improve working memory performance and increase activation of regions under-functioning in ADHD. Additionally, methylphenidate has been observed to modulate functional networks involved in working memory. No research, however, has examined the effects of atomoxetine or compared the two drugs.

Objectives

This study aimed to test methylphenidate and atomoxetine effects on functional connectivity during working memory in boys with ADHD.

Methods

We tested comparative effects of methylphenidate and atomoxetine on functional connectivity during the n-back task in 19 medication-naïve boys wi

SUBMITTER: Kowalczyk OS 

PROVIDER: S-EPMC10506949 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature