Operant novelty seeking predicts cue-induced reinstatement following cocaine but not water reinforcement in male rats.

ABSTRACT:

Rationale

An important facet of cocaine addiction is a high propensity to relapse, with increasing research investigating factors that predispose individuals toward uncontrolled drug use and relapse. A personality trait linked to drug addiction is high sensation seeking, i.e., a preference for novel sensations/experiences. In an animal model of sensation seeking, operant novelty seeking predicts the acquisition of drug self-administration.

Objective

The primary goal of this research was to evaluate the hypothesis that sensitivity to the reinforcing effects of novel sensory stimuli predicts more intensive aspects of drug-taking behaviors, such as relapse.

Methods

Rats were first tested for Operant Novelty Seeking, during which responses resulted in complex visual/audit

SUBMITTER: Gancarz AM 

PROVIDER: S-EPMC10506955 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature