Ecophysiology and interactions of a taurine-respiring bacterium in the mouse gut.

ABSTRACT: Taurine-respiring gut bacteria produce H₂S with ambivalent impact on host health. We report the isolation and ecophysiological characterization of a taurine-respiring mouse gut bacterium. Taurinivorans muris strain LT0009 represents a new widespread species that differs from the human gut sulfidogen Bilophila wadsworthia in its sulfur metabolism pathways and host distribution. T. muris specializes in taurine respiration in vivo, seemingly unaffected by mouse diet and genotype, but is dependent on other bacteria for release of taurine from bile acids. Colonization of T. muris in gnotobiotic mice increased deconjugation of taurine-conjugated bile acids and transcriptional activity of a sulfur metabolism gene-encoding prophage in other commensals, and slightly decreased the abundan

SUBMITTER: Ye H 

PROVIDER: S-EPMC10507020 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature