A multicenter prospective study of comprehensive metagenomic and transcriptomic signatures for predicting outcomes of patients with severe community-acquired pneumonia.

ABSTRACT:

Background

Severe community-acquired pneumonia (SCAP) results in high mortality as well as massive economic burden worldwide, yet limited knowledge of the bio-signatures related to prognosis has hindered the improvement of clinical outcomes. Pathogen, microbes and host are three vital elements in inflammations and infections. This study aims to discover the specific and sensitive biomarkers to predict outcomes of SCAP patients.

Methods

In this study, we applied a combined metagenomic and transcriptomic screening approach to clinical specimens gathered from 275 SCAP patients of a multicentre, prospective study.

Findings

We found that 30-day mortality might be independent of pathogen category or microbial diversity, while significant difference in host gene expression p

SUBMITTER: Zhao J 

PROVIDER: S-EPMC10507133 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature